Never underestimate your friendly neighborhood Spider-Man, even with a mutating virus afoot. Despite rising concerns over the omicron variant, “Spider-Man: No Way Home” not only shattered pandemic-era box office records; it became the third best opening of all time behind “Avengers: Endgame” ($357.1 million) and “Avengers: Infinity War" ($257.7 million).

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Comscore. Final domestic figures will be released Monday.

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